GenEx: Generative Augmentation of Scarce Data through Expert Guidance for Personalized Dosing [SSRN]
Runner-Up, INFORMS Health Applications Society Best Student Paper Competition (2025)
Personalized treatment optimization is constrained by data scarcity, especially for rare patient profiles, limiting individualized and safe dosing recommendations. We introduce GenEx, a hybrid framework integrating preference-based Bayesian optimization with a generative model fine-tuned via expert feedback. A trust-gated component proposes synthetic data in uncertain regions, while pairwise expert rankings guide updates to both surrogate and generator. A retrospective tacrolimus study in kidney transplant recipients demonstrates a mean 25.9% improvement in treatment utility, with gains retained under noisy feedback. GenEx is humans augmenting AI as much as it is AI augmenting humans.